P. 40

 Glial and vascular contributions to neurodegenerative diseases
Poster Session II,Tuesday 11 October,18.00 - 19.30
Single cell transcriptomics of vascular cells from App knock-in mice reveal increased vascular tonus and activation of inflammatory pathways
Katrine Dahl Bjørnholm1, Michael Vanlandewijck2,3, Urban Lendahl2, Francesca Del Gaudio2, Helena Karlström1, Christer Betsholtz2,3, Per Nilsson1
1Karolinska Institutet, Department of Neurobiology Care Science and Society, Section of Neurogeriatrics, Solna, Stockholm, Sweden 2Karolinska Institutet, Department of Medicine Huddinge, Huddinge, Stockholm, Sweden
3Uppsala University, Institute for Immunology, Genetics, and Pathology, Uppsala, Sweden
Investigation of functional and Structural Changes of Retina in a murine Model of Alzheimer’s Disease
Chae-Eun Moon1,2, Kyusun Han1, Hae-Sol Shin1,3,Yejun Cho1, Jun Ki Lee1,
Hyun Jin Kim1, Hong Kyung Kim1,3, Suk Ho Byeon1,2, Kyoung Yul Seo1,3, Hyung Keun Lee1, Yong Woo Ji1,4
1Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea 2Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
3Korea Mouse Sensory Phenotyping Center, Yonsei University College of Medicine, Seoul, Korea
4Department of Ophthalmology, Yongin Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
Phospholipase D3 deficiency compromises mitochondrial DNA degradation leading to lysosomal dysfunction and membrane lipid alterations
Zoë P. Van Acker1, Marine Bretou1, Ragna Sannerud1, Markus Damme2, Wim Annaert1 1VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium
2Christian-Albrechts-University Kiel Institute of Biochemistry, Kiel, Germany
Modelling discontinuous flow patterns on the blood-brain barrier
1,2 2,3 4,5 Adjanie Patabendige , Gregory Lip , Damir Janigro
1Edge Hill University, Ormskirk, UK
2University of Liverpool, Liverpool, UK
3Liverpool Heart & Chest Hospital, Liverpool, UK
4Flocel Inc, Cleveland, USA, 5Case Western Reserve University, Cleveland, USA
Cerebral metabolic changes and impaired blood-brain barrier precede amyloid beta deposition in the 5×FAD mouse model
Minmin Yao1, Zhiliang Wei2, Ziqin Zhang3, Anna Li4, Ruoxuan Li1, Aaron Kakazu1, Hanzhang Lu2,3, Jiadi Xu2,4, Wenzhen Duan1,5
1Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of medicine, Baltimore, USA 2The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, USA 3Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA, Baltimore, USA
4F.M. Kirby Research Center, Kennedy Krieger Research Institute, Baltimore, USA
5Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, USA
40 • ISMND 2022
10 -12 October
Divani Acropolis Athens Greece

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