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 Glial and vascular contributions to neurodegenerative diseases
PP56 PP57
Implication of apoE in the crosstalk of meningeal lymphatic function and innate immunity
Nikoleta Delivanoglou1, Kennedi Todd3, Sofia Pereira Das Neves1, Megan J. Barber1, Guadalupe Sanchez1,2,Yuka Martens1, Silvia S. Kang1, John D. Fryer3, Guojun Bu1, Sandro Da Mesquita1,2
1Department of Neuroscience, Mayo Clinic, Jacksonville, USA
2Neuroscience Ph.D. Program, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Jacksonville, USA 3Department of Neuroscience, Mayo Clinic, Scottsdale, USA
Poster Session II,Tuesday 11 October,18.00 - 19.30
LRP1 is a neuronal receptor for α-synuclein uptake and spread
1 1 1 1 2 1
Na Zhao ,Kai Chen ,Yuka Martens ,Axel Meneses ,Daniel Ryu ,Wenyan Lu ,
Ana Caroline Raulin1, Fuyao Li1, Jing Zhao1, Yixing Chen1, Cynthia Linares1,
Marshall Goodwin2,Yonghe Li1, Chia-Chen Liu1,Takahisa Kanekiyo1, David Holtzman3, Todd Golde2, Guojun Bu1
1Mayo Clinic, Jacksonville, USA
2University of Florida, Gainesville, USA
3Washington University School of Medicine, St. Louis, USA
FDA-approved small molecule drugs inhibit the interaction of apolipoprotein E with amyloid-β and show evidence of improving cognition in Alzheimer’s disease patients
Noah Johnson1, Athena Ching Jung Wang1, Christina Coughlan1, Stefan Sillau1, Esteban Lucero1, Lisa Viltz1, Neil Markham1, Cody Allen1, A. Ranjitha Dhanasekaran1, Heidi Chial1, Huntington Potter1
1Department of Neurology, University of Colorado Alzheimer’s and Cognition Center, and the Linda Crnic Institute for Down Syndrome, University of Colorado, Anschutz Medical Campus, USA
Neurotoxicity in Frontotemporal Dementia 3 is caused by Altered Microglia Metabolism and Inflammatory Profile
Henriette Haukedal, Signe Lorenzen, Kristine Freude1
1University of Copenhagen, Frederiksberg, Denmark
Contraction of brain pericytes in response to Islet Amyloid PolyPeptide is reversed by pramlintide
Cristina Nunez-diaz1, Dovilė Pocevičiūtė1, Nina Schultz1, B The Netherlands Brain Bank N B2, Karl Swärd3, Malin Wennström1
1Clinical Memory Research Unit, Department of Clinical Sciences Malmö,Lund University, Malmö, Sweden 2Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA, Amsterdam, Netherlands 3Department of Experimental Medical Science, BMC D12, SE-22184, Lund, Sweden
Long-read RNA sequencing reveals new and diverse genes and RNA isoforms expressed in human brain
Mark Ebbert1,2,3, Bernardo Aguzzoli-Heberle1,2, J. Anthony Brandon1,2, Kayla A. Nations1,2, Madeline Page1,2, Mark E. Wadsworth1,2, Dennis Dickson4, Peter T. Nelson1, John D. Fryer5
1Sanders-brown Center On Aging, University Of Kentucky College of Medicine, Lexington, USA
2Department of Neuroscience, University of Kentucky College of Medicine, Lexington, USA
3Division of Biomedical Informatics, Internal Medicine, University of Kentucky College of Medicine, Lexington, USA 4Department of Neuroscience, Mayo Clinic, Jacksonville, USA
5Department of Neuroscience, Mayo Clinic, Scottsdale, USA
10 -12 October
Divani Acropolis Athens Greece

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