P. 33

 Glial and vascular contributions to neurodegenerative diseases
Poster Session I, Monday 10 October, 18.00 - 19.30
Identification of novel regulators of the TREM2 pathway using arrayed CRISPR screens with iPSC derived human microglia-like cells
Fangfang Bai1, Jean Paul Chadarevian2, Aaron Wolman1, Alex Tamburino1,
Carlo Ramil1, Sidney Hsieh1, Choya Yoon1, Tobias Ehrenberger1, Aleksandra Olow1, Federica Piccioni1, An Chi1, Matthew Kennedy1, Hayk Davtyan2, Matthew Blurton-Jones2, Vanessa Peterson1, Rebecca Mathew1
1MSD, Cambridge, USA
2UCI, Department of Neurobiology and Behavior, Irvine, USA
The effects of elevated BIN1 isoform 9 expression in mature oligodendrocytes on myelination and AD pathophysiology in the 5XFAD mouse model
Melike Yuksel1, Mitch Hansen1, Robert J. Andrew2, Moorthi Ponnusamy, Gopal Thinakaran1
1Department of Molecular Medicine and USF Health Byrd Alzheimer’s Center and Research Institute, University of South Florida, Tampa, USA 2Department of Neurobiology, The University of Chicago, Chicago, USA
Astrocytic urea cycle detoxifies Aβ-derived ammonia while impairing memory in Alzheimer’s Disease
Mridula Bhalla1,2, Yeonha Ju1,2, Seung Jae Hyeon3, Ju Eun Oh4, Seonguk Yoo4, Uikyu Chae3,Jea Kwon1,5,Wuhyun Koh1,Jiwoon Lim1,2,Yongmin Mason Park1,2, JungHee Lee6, Il Joo Cho3,7,8, Hyunbeom Lee4, Hoon Ryu3, Drq C Justin Lee1,2
1Center for Cognition and Sociality, Institute For Basic Science (IBS), Daejeon, South Korea
2IBS School, University of Science and Technology (UST), Daejeon, South Korea
3Brain Science Institute (BSI), Korea Institute of Science and Technology (KIST), Seoul, South Korea
4Center for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, Seoul, South Korea
5Korea University-Korea Institute of Science and Technology, Graduate School of Convergence Technology, Korea University, Seoul, South Korea 6Boston University Alzheimer’s Disease Research Center and Department of Neurology, Boston University School of Medicine, Boston, USA 7School of Electrical and Electronics Engineering, Yonsei University, Seoul, South Korea
8Yonsei-KIST Convergence Research Institute, Yonsei University, Seoul, South Korea
PP28 Targeting astrocyte glutamate transporter EAAT2 in Alzheimer's disease Lloyd Tran1, Markku Kurkinen
1Biomed Industries, Inc., San Jose, USA
Chronic effects of a low glycemic index diet in neuroinflammation in the 5xFAD mouse model of Alzheimer's disease
Ioannis Dafnis1, Christina Mountaki1, Eleni Fanarioti2, Dimitrios C. Mastellos1, Michalis Karvelas3, Vaios T. Karathanos4, Athina Tzinia1, Catherine R Dermon2, Angeliki Chroni1
1National Center For Scientific Research Demokritos, Athens, Greece 2University of Patras, Patras, Greece
3Agricultural Cooperatives' Union of Aeghion, Aeghion, Greece 4Harokopio University, Athens, Greece
10 -12 October
Divani Acropolis Athens Greece

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