P. 31

 Glial and vascular contributions to neurodegenerative diseases
Peptide aptamer (PA8) targeting Aβ-PrP-Fyn axis reduces activated gliosis and improves memory function in 5XFAD transgenic mouse model
Tahir Ali1,2, Antonia N. Klein1,2, Alex Vu1,2, Sabine Gilch1,2
1Calgary Prion Research Unit, Department of Comparative Biology & Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Canada
2Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada
Levels of AD associated plasma biomarkers increase with age which may obscure an association with cognitive performance in the oldest old
Linda Lorenz1,2,3, Meng Zhang1,4, Niccolo Tesi1,4, Sven Van der Lee1,2,3, Marc Hulsman1,2,4, Mariam Gouda5, Sietske Sikkes1,6,7, Charlotte Teunissen5, Henne Holstege1,2,3,4
1Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands
2Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands 3Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands
4Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands
5Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
6Department of Epidemiology & Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
7Faculty of Behavioural and Movement Sciences, Clinical Developmental Psychology and Clinical Neuropsychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Estrogen receptor beta modulates microglia activation in Alzheimer’s disease pathology
Aphrodite Demetriou1, Mukesh Varshney1, Ivan Nalvarte1
1Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
The coarse-grained plaque is an aberrant Aβ plaque associated with astrogliosis and pTau burden in APOE4 Alzheimer’s disease
Baayla D.C. Boon1, Naomi Kouri1, Sydney A. Labuzan1, Jessica F. Tranovich1, Isabelle Frankenhauser2, Christian Lachner1, Nilüfer Ertekin-Taner1, Ranjan Duara2, Neill R Graff-Radford1, Dennis W Dickson1, Melissa Murray1
1Mayo Clinic, Jacksonville, USA 2Parcelsus Medical University, Austria 3Mount Sinai Medical Center, Miami, USA
The role of ABI3 in microglia functions and the pathogenesis of Alzheimer’s disease
Hande Karahan1,2, Daniel C. Smith1, Byungwook Kim1,2, Luke C. Dabin1,2, Mamun Al-Amin1,2, Sagara Wijeratne1,Taylor Pennington1,2, Gonzalo Viana di Prisco1,2, Brianne McCord1,2, Peter Lin1,Adrian L.Oblak1,2,Shaoyou Chu1,Brady K.Atwood1,2,Jungsu Kim1,2
1Indiana University School of Medicine, Indianapolis, USA
2Stark Neurosciences Research Institute, Indianapolis, USA
PP17 PP18
Poster Session I, Monday 10 October, 18.00 - 19.30
10 -12 October
Divani Acropolis Athens Greece

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