Page 28 - ISMND_PROGRAM
P. 28

 Glial and vascular contributions to neurodegenerative diseases
Poster Session I, Monday 10 October, 18.00 - 19.30
PP01
The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer’s disease mouse model
Christel Claes1, Whitney England1, Emma Danhash1, Sepideh Kiani Shabestari1, Jean Paul Chadarevian1, Amit Jairaman1, Jonathan Hasselmann1, AndyTsai2, Morgan Coburn1, Jessica Sanchez1, Tau Lim1, Jorge Hidalgo1, Christina Tu1, Michael Cahalan1, Bruce Lamb2, Gary Landreth2, Robert Spitale1, Mathew Blurton-Jones1, Hayk Davtyan1
1University Of California Irvine, Irvine, USA
2Indiana University School of Medicine, Indianapolis, USA
Understanding human trem2-dependent microglial responses to alzheimer’s disease pathology in vivo with chimeric mice
Hayk Davtyan1, Jonathan Hasselmann1, Alex M. Tamburino2, Jean Paul Chadarevian1, Yun Jiao2, Carlo Ramil2, Minxue Jia2, Dan Chang2, Alina Lahian1, Christina Tu1, Sepideh Kiani Shabestari1, Joia Capocchi1,Nandita Joshi2, Christian Mirescu2,An Chi2,Vanessa Peterson2,Matthew Kennedy2,Mathew Blurton-Jones1, Rebecca Mathew2
1University of California Irvine, Irvine, USA
2Merck Sharp & Dohme Corp. (MSD), Boston, USA
Plasma apoe3 levels in relation to sex, behavioural and cognitive phenotypes in apoeε3/ε3 humanized-liver and targeted replacement mice
Andreas Giannisis1, Kat Kessler2, Greg Bial3, Lander Foquet3, Henrietta M. Nielsen1, Jacob Raber2,4
1Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden
2Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, USA
3Yecuris Corporation, Tualatin, USA
4Department of Neurology and Radiation Medicine, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Portland, USA
Effects of ACE1 knockout on tau pathology, amyloid deposition, and neurodegeneration in AD-relevant mouse models
Leah K Cuddy1, Alia Alia1, Miranda Salvo1, Jelena Popovic1, Dmitry Prokopenko3, Rudolph Tanzi4, Robert Vassar1,2
1The Ken and Ruth Davee Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, USA
2Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Feinberg School of Medicine, Chicago, USA 3Genetics and Aging Unit and McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Boston, USA 4Genetics and Aging Unit and McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Boston, USA
BACE1 controls synaptic function through modulating release of synaptic vesicles
Brati Das1, Neeraj Singh1, Annie Y. Yao1, John Zhou, Wanxia He, Xaingyou Hu, Riqiang Yan1
1UConn Health Center, USA
PP02
PP03
PP04
PP05
28 • ISMND 2022
10 -12 October
Divani Acropolis Athens Greece
2022



































































   26   27   28   29   30