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 Glial and vascular contributions to neurodegenerative diseases
SCIENTIFIC PROGRAM Day 1, Monday, October 10
08:30 – 08:45
08:45 – 10:25
VIRTUAL VIRTUAL
10:25 – 10:50 10:50 – 12:30
WELCOME REMARKS
12:30 – 14:00 14:00 - 15:20
LUNCH BREAK/EXHIBITS
Session III: ROLE of APOE IN NEURODEGENERATION
Chair: Riqiang Yan, University of Connecticut School of Medicine, USA
14 • ISMND 2022
ISMND 2022 Organizing Committee and BrightFocus Foundation
Session I: GLIAL CONTRIBUTIONS TO NEURODEGENERATION FROM CLINICAL AND NEUROPATHOLOGICAL PERSPECTIVES
Chair: Guojun Bu, Molecular Neurodegeneration, USA
08:45 – 09:05
09:05 – 09:25 09:25 – 09:45
09:45 – 10:05
Microglia activation in Alzheimer’s disease from a neuropathological perspective
Jeroen Hoozemans,Amsterdam UMC,The Netherlands
Neuropathologic spectrum of neuroglial tauopathies
Dennis Dickson, Mayo Clinic Florida, USA
Reactive astrogliosis studies by translational multimodal imaging in neurodegenerative Diseases
Agneta Nordberg, Karolinska Institutet, Sweden
Identification and validation of pathways and clinical biomarkers for the three major dementias by an optimised CSF and blood proteomics workflow
Charlotte Teunissen, Amsterdam UMC, The Netherlands
Neuronal basis of sleep disturbances in neurodegenerative diseases: clinical, diagnostic and therapeutic implications
Lea Grinberg, University of California San Francisco, USA
10:05 – 10:25
COFFEE BREAK/EXHIBITS
Session II: GLIAL MECHANISMS OF NEURODEGENERATION Chair: Robert Vassar, Northwestern University, USA
10:50 – 11:10 11:10 – 11:30 11:30 – 11:50 11:50 – 12:10 12:10 – 12:30
Lysosomal regulation of glial function and immune activation
Hui Zheng, Baylor College of Medicine, USA
Reactive astrocytes as the cause of Alzheimer’s disease
Justin Lee, Institute for Basic Science, South Korea
Targeting maladaptive immune response for AD and tauopathy
Li Gan, Weill Cornell School of Medicine, USA Target BACE1 inhibition in glial cells for AD
Riqiang Yan, University of Connecticut School of Medicine, USA
Plasticity and dynamics of brain macrophages: from homeostasis to disease and back
Kiavash Movahedi, Vrije Universiteit Brussels, Belgium
14:00 - 14:20 14:20 - 14:40
14:40 – 15:00 15:00 - 15:20
ApoE in AD: Lessons from common and rare variants
Guojun Bu, Molecular Neurodegeneration, USA
Role of APOE, microglia, and the immune response in tau mediated neurodegeneration
David Holtzman, Washington University in St Louis, USA
Translational lessons on apoE
Henrietta Nielsen, Stockholm University, Sweden
Lipoprotein inflammatory pathways that influence neurodegenerative pathology
John Fryer, Mayo Clinic Arizona, USA
10 -12 October
Divani Acropolis Athens Greece
2022













































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